Plasticity of Tumor Suppressor Functionality of p53 Includes Potential Carcinogenesis in Terms of Subsequent Progression of the Malignant Transformation Event

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چکیده

Provoking plasticity of response of p53 involves mutations of the p53 gene within the further contextual accumulation of p53 protein within the cell cytoplasm. Activation of wild-type p53 gene and protein includes various post-translational modifications including specific phosphorylation and mutability performance of the core DNA binding domain in particular. Rigorous characterization and re-characterization of the essential accumulation of mutant p53 within the cytoplasm is itself a characterized reformulation of the essential transformation step per se and includes the dynamics of DNA damage repair that indicates malignant transformation a strict attribute of the initial DNA damage as structural dynamics of subsequent progression of potential carcinogenesis.

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Plasticity of Tumor Suppressor Functionality of p53 Includes Potential Carcinogenesis in Terms of Subsequent Progression of the Malignant Transformation Event

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تاریخ انتشار 2017